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IMPORTANT SAFETY INFORMATION

What is the most important information I should know about Effient?

Effient^® (prasugrel) can cause bleeding. If you have unexplained or excessive bleeding while on Effient, contact your doctor right away as some bleeding can be serious, and sometimes fatal. Do not take Effient if you currently have abnormal bleeding, such as stomach or intestinal bleeding, bleeding in your head, or have a history of stroke, or “mini-stroke” (also known as transient ischemic attack or TIA).

Get medical help right away if you suddenly have slurring of speech, weakness or numbness in one part of your body, blurry vision, and/or severe headache. These may be symptoms of a stroke or TIA. If you have a stroke or TIA while taking Effient, your doctor will probably stop your Effient.

Before having any surgery, you should talk to your doctor about stopping Effient. If possible, Effient should be stopped at least 1 week (7 days) before any surgery, as instructed by the doctor who prescribed Effient for you.

You may also have a higher risk of bleeding if you take Effient and you: a) are age 75 or older, b) weigh less than 132 pounds, c) are taking anticoagulants (eg, warfarin) or regular daily use of NSAIDs, d) have had recent trauma, such as an accident or surgery, e) have severe liver problems, or f) have a stomach ulcer.

Do not stop taking Effient without talking to the doctor who prescribes it for you. People who are treated with angioplasty and have a stent, and stop taking Effient too soon, have a higher risk of a blood clot in the stent, having a heart attack, or dying.

What should I tell my doctor before taking Effient?

Tell your doctor about all of your medical conditions, allergies, and medicines you are taking.

What are the possible side effects of Effient?

Bleeding is the most common side effect of Effient.

TTP, a rare but life-threatening condition, has been reported with Effient, sometimes after a short time (less than 2 weeks). Get medical attention right away if you develop the following unexpected symptoms of TTP: fever, weakness, yellowing of the skin or eyes, or if skin becomes very pale or dotted with purple spots.

Serious allergic reactions can happen with Effient, or if you have had a serious allergic reaction to the medicines Plavix^® (clopidogrel) or ticlopidine. Get medical help right away if you get any of these symptoms of a severe allergic reaction: swelling or hives of your face, lips, in or around your mouth, or throat, trouble breathing or swallowing, chest pain or pressure, dizziness or fainting.

Other side effects may occur. For more information, talk to your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information about Effient, please see the Full Prescribing Information, including Boxed Warning regarding bleeding risk, and Medication Guide.

PGDTCISI03Oct2011.

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Ease Into Exercise

Exercise is a proven way to control your risk factors for heart disease and help maintain overall mental and physical health. By making exercise a regular part of your daily routine, you can enjoy any or all of the benefits below:

Strengthened heart and lungs
Improved circulation
Increased endurance
Lowered blood pressure

Talk to Your Doctor

Always check with your doctor first before starting an exercise program. Your doctor can help you find a cardiac rehab program that matches your level of fitness and overall health.

Here is a list of questions to ask:

How much should I exercise every day?
How much exercise is right for me each week?
What kind of exercise do you recommend for me?
Are there activities I should avoid?
Will taking my medication have any impact on how or when I exercise?
While exercising, should I check my pulse?

Tips for a Successful Exercise Program

As you begin exercising, consider these tips to help make your cardiac rehab program a successful one.

Take it slow
It's great to be enthusiastic about exercise, just don't get carried away too soon. Work with your doctor to determine what level of exercise is right for you.

Keep it fun and comfortable
Why not get your exercise doing something you like? It could be working out at the gym, walking, dancing, biking, or even working in the yard or garden. To make exercise even more enjoyable, try wearing loose, comfortable clothes, and supportive footwear. Try listening to your favorite music while you exercise.

Get some support
Finding an exercise "buddy" is a great way to keep motivated. Even when no workout partner is available, you can still look to friends and family for support and encouragement. All you have to do is ask.

Mix it up
Identify a variety of activities you enjoy and switch between them on a regular basis. That way you'll avoid the risk of exercise seeming boring or stale.

You can also get your exercise while doing household chores like vacuuming, dusting, and mowing the lawn.

Create a schedule
Even the best fitness program is worthless if you can never seem to fit it into your day. Find the best location and most convenient time to plan your workout. Then make it a priority by writing it into your daily schedule. Of course, there will be times when you can't keep your exercise "appointment." When that happens, just get back on track the next day.

Note your success
Note your exercise activity, so you can track your progress and success. When you achieve a milestone, do something to reward yourself. You should enjoy the good job you're doing.

Go by the numbers
It's a lot easier to exercise properly and measure your progress when you know two important numbers: your body mass index (BMI) and your target heart rate. BMI is a measure of your weight scaled according to your height. Learn more about BMI from the American Heart Association site. You can determine your target heart rate by monitoring your pulse while exercising. Your target heart rate is a range that stays within 60% to 85% of your maximum heart rate.

Click here to read about the value of reducing stress.

Learn about your stent procedure.

Effient is indicated to help reduce the risk of a future heart-related event, such as a heart attack or stent clot, in patients who had an acute coronary syndrome (ACS) event that was treated with angioplasty. The loading dose of Effient is 60 mg and the maintenance dose is 10 mg once daily. Effient is available in 5-mg and 10-mg tablets.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about Effient?

What should I tell my doctor before taking Effient?

Tell your doctor about all of your medical conditions, allergies, and medicines you are taking.

What are the possible side effects of Effient?

Bleeding is the most common side effect of Effient.

Other side effects may occur. For more information, talk to your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information about Effient, please see the Full Prescribing Information, including Boxed Warning regarding bleeding risk, and Medication Guide.

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^®Effient and the Effient logo are registered trademarks of Eli Lilly and Company.
™Esstential Habits and the Esstential Habits logo are trademarks of Eli Lilly and Company.
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Copyright © 2011 Daiichi Sankyo, Inc. and Lilly USA, LLC. All Rights Reserved. PG71870 10/2011. PGDTCISI03Oct2011.